Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found that rs334555, located in intron 1 of GSK3β, was nominally associated with an earlier AAO of the disease in MDD (P = 0.001).
|
20618448 |
2010 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Analyzing patient subgroups, GSK3B structural variants were found to be risk factors of BP particularly (P = 0.00001) with an odds ratio of 8.1 while no such effect was shown in the MDD group.
|
24677591 |
2014 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
We now investigate an algorithm-derived comprehensive list of genes encoding proteins that directly interact with GSK3β to identify a genotypic network influencing hippocampal volume in MDD.
|
30080747 |
2018 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results provide evidence that the GSK3B gene could be a promising region which contains genetic risk for both major depressive disorder and schizophrenia in the Han Chinese population.
|
26186530 |
2015 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analysis of the genotyping data extracted from our hospital database revealed that rs334558 exhibited exclusive association with MDD in female patients (P=0.015).Our findings suggest that GSK3β rs334558 polymorphisms might be a potential risk for MDD, and females with GSK3β rs334558 polymorphisms might have higher penetrance of MDD.
|
28099358 |
2017 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Parallels between major depressive disorder and Alzheimer's disease: role of oxidative stress and genetic vulnerability.
|
24927694 |
2014 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although no significant association between GSK3β SNPs and MDD was found, some genotypes and haplotypes were associated with anxiety symptoms in MDD.
|
23030648 |
2012 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our findings show, for the first time, that GSK3B genetic variants play a role in the SSRI antidepressant therapeutic response and support the hypothesis that drugs regulating GSK3B activity may represent a novel treatment strategy for MDD.
|
18195729 |
2008 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here we provide supporting observations by showing that polymorphisms in additional genes encoding proteins directly related to GSK3beta biological functions are associated with similar regional grey matter (GM) volume changes in MDD patients.
|
20219685 |
2010 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Taken together, these findings support the assertion that the GSK3B gene is an important susceptibility factor for MDD in a Han Chinese population.
|
20033742 |
2010 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analyzing patient subgroups, GSK3B structural variants were found to be risk factors of BP particularly (P = 0.00001) with an odds ratio of 8.1 while no such effect was shown in the MDD group.
|
24677591 |
2014 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
A haplotype of glycogen synthase kinase 3β is associated with early onset of unipolar major depression.
|
20618448 |
2010 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
We then highlight evidence suggesting that GSK3β influences hippocampal volume in MDD patients, and how this could assist with targeting more precise treatments particularly for cognitive deficits in patients with mood disorders.
|
30310078 |
2018 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Other interacting molecular signals, i.e., GSK-3β, convergent survival factors (brain-derived neurotrophic factor and heat shock proteins), and transition redox metals are also mentioned to emphasize the vast array of intermediates that could interact via comparable mechanisms in both MDD and AD.
|
24927694 |
2014 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we examined the relationship between brain volume-related SNPs of the GSK-3β gene and antidepressant treatment effects in patients with MDD.
|
31189175 |
2019 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Homozygous CC genotype of 3111T/C, GSK3B-AT/TT genotype of rs33458 and haplotype of TPH1 218A/C were associated with insomnia symptom of MDD.
|
31111219 |
2019 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Diurnal alterations in circadian genes and peptides in major depressive disorder before and after escitalopram treatment.
|
24001941 |
2013 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Under a dominant model, we observed a potential association between the GSK3B rs6782799 and MDD (P=0.07), a significant three-way interaction among BDNF rs6265, GSK3B rs6782799, and negative life events (corrected P-value, 0.011-0.012; cross-validation consistency, 7; prediction error, 0.4349).
|
20682308 |
2010 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Possible association of the GSK3β gene with the anxiety symptoms of major depressive disorder and P300 waveform.
|
23030648 |
2012 |